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Inflammasome- A Novel Mechanism of Innate Immunity In Periodontal Disease
Deepthi K1, Jagadish Reddy2, Raja Babu. P3, Vikram Reddy4
1Post Graduate Student, Department of Periodontics, Kamineni institute of dental sciences. Narketpally, Nalgonda, Telangana.
2&4Reader, Department of Periodontics, Kamineni institute of dental sciences. Narketpally, Nalgonda, Telangana.
3Professor & HOD, Department of Periodontics, Kamineni institute of dental sciences. Narketpally, Nalgonda, Telangana.
Email for correspondence: drdeepthikannam@gmail.com
Received: April 10, 2016
Review Completed: May 11, 2016
Accepted: June 9, 2016
Available Online: September, 2016
Review Completed: May 11, 2016
Accepted: June 9, 2016
Available Online: September, 2016
doi: 10.5866/2016.8.10094
ABSTRACT
Periodontitis is a chronic inflammatory disease. Besides microbiota, various other risk factors also play a role in the progression of periodontal disease. Host immune system prevents the progression of periodontal disease by clearing the microbiota. Immune system consists of innate and adaptive mechanism which control of periodontal disease. Innate immune system is non-specific and various mechanisms and cells play key role in the arrest of periodontal disease. Recently the role of inflammasome complex is explored in arresting periodontal disease. This review highlights the inflammasome, the regulation and the role of inflammasome in the periodontal disease.
Key words: Inflammasome, innate immunity, periodontitis